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This research examines the role of RAGE in peripheral nerve regeneration following injury.

Antagonism of RAGE suppresses peripheral nerve regeneration

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Randomized trial demonstrates impaired nerve recovery in mice with RAGE blockade, suggesting critical regenerative role.

This research examines the role of RAGE in peripheral nerve regeneration following injury.
Mice underwent unilateral sciatic nerve crush for nerve injury.
RAGE was blocked using soluble RAGE or antibodies against RAGE and its ligands.
Functional recovery was assessed using motor and sensory nerve conduction velocities and sciatic functional index.
In RAGE-blocked mice, functional recovery was significantly reduced as indicated by lower nerve conduction velocities (p<0.01).
Reduced myelinated fiber density was observed, indicating impaired nerve regeneration (p<0.05).
Fewer infiltrating mononuclear phagocytes were found in the distal nerve segments after RAGE blockade.

Rong et al. (2004) studied this question.

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