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This is the first report in a projected series on neurological development among the offspring of schizophernics. An increased incidence of fetal and neonatal deaths is noted among offspring of schizophrenics when compared to a closely matched control group, using data collected prospectively. In many cases, no apparent reason for death was determined; in some cases, major neurological malformations were found. It is necessary to consider three possible explantions for these findings--genotype of the child, adverse intrauterine environment, and medication toxicity.
Ronald O. Rieder (Sat,) studied this question.