Key result
In patients with T2DM and NSTEMI, increased HbA1c (>6.5%) was significantly related to coronary thrombus scale in the target vessel (P<0.05).
Why the study?
The study aimed to investigate the relationship between HbA1c and coronary thrombus load in T2DM patients presenting with NSTEMI.
Does elevated HbA1c (>6.5%) correlate with increased coronary thrombus load in patients with T2DM and NSTEMI?
Observational (n=90)
Does elevated HbA1c (>6.5%) correlate with increased coronary thrombus load in patients with T2DM and NSTEMI?
p-value: p=< 0.05
In patients with T2DM and NSTEMI, elevated HbA1c (>6.5%) is significantly associated with higher coronary thrombus burden, suggesting a potential need for stricter anticoagulation in this subgroup.
HbA1c >6.5% flags higher thrombus burden in diabetic NSTEMI; extends observational links to acute coronary pathology.
BACKGROUND: We aimed to investigate the relationship between hemoglobin A1c (HbA1c) and coronary thrombus load in type-2 diabetes mellitus (T2DM) patients with non-ST segment elevation myocardial infarction (NSTEMI). MATERIALS AND METHODS: Ninety diabetic patients with NSTEMI were recruited for the study. They were separated into two groups according to HbA1c levels. Forty-seven patients having HbA1c ≤6.5% formed Group-I (35 male, mean age 58 ± 10.5 years) and the remaining 43 patients with HbA1c >6.5% formed Group-II (23 male, mean age 58 ± 11.1 years). Both the groups were evaluated in terms of thrombolysis in myocardial infarction (TIMI) thrombus score and Syntax score. RESULTS: < 0.05). No significant difference was found in other parameters. In stepwise linear regression analysis, prepercutaneous coronary intervention (PCI) and post-PCI TIMI frame number and HbA1c were significantly related to the coronary thrombus scale. However, no significant relationship has been found between thrombus formation and hypertension, previous PCI history, pre-PCI heart rate, pre-PCI cholesterol status, and high-sensitive troponin T. CONCLUSION: In NSTEMI with T2DM, increased HbA1c (HbA1c >6.5%) is related with coronary thrombus in the target vessel. In those patient population, strict anticoagulation should be considered to prevent potential adverse events.
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Topal et al. (2021) conducted an observational in Type 2 diabetes mellitus with non-ST segment elevation myocardial infarction (NSTEMI) (n=90). HbA1c >6.5% vs. HbA1c ≤6.5% was evaluated on Coronary thrombus scale (TIMI thrombus score and Syntax score) (p=< 0.05). In patients with T2DM and NSTEMI, increased HbA1c (>6.5%) was significantly related to coronary thrombus scale in the target vessel (P<0.05).
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