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Abstract A useful synthetic method for building up multisubstituted arenes of structural complexity and diversity by use of aromatic reactive intermediates is described. Regardless of the transient character arising from a highly strained carbon–carbon triple bond, arynes have been found to undergo facile insertion into an element–element σ-bond and three-component coupling reactions. In addition, ortho-quinone methides and ortho-quinodimethanes have also been demonstrated to be convertible into multisubstituted arenes by utilizing their exo-dienyl moieties.
Yoshida et al. (Thu,) studied this question.