Key result
Coincubation of urate crystals and neutrophils in the presence of 10 µg/ml low-density lipoprotein resulted in 83% inhibition of crystal-induced chemiluminescence.
Effect estimate: 83% inhibition
Apoprotein B-containing lipoproteins bind to urate crystals and profoundly inhibit crystal-induced neutrophil activation, suggesting they may regulate the inflammatory response in gouty arthritis.
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Lipoproteins may regulate gouty inflammation; hypothesis-generating from Level 5 data and requires human confirmation.
Terkeltaub et al. (1984) studied Gouty arthritis (in vitro model). Lipoproteins containing apoprotein B (LDL) vs. Buffer or lipoprotein-depleted plasma was evaluated on Urate crystal-induced neutrophil luminol-dependent chemiluminescence (83% inhibition). Coincubation of urate crystals and neutrophils in the presence of 10 µg/ml low-density lipoprotein resulted in 83% inhibition of crystal-induced chemiluminescence.
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