Key result
Olprinone significantly increased heart rate and systemic flow, and reduced atrial pressure and systemic vascular resistance in patients with a large ventricular septal defect.
Why the study?
Does olprinone improve hemodynamic parameters in patients with a large ventricular septal defect?
Does olprinone improve hemodynamic parameters in patients with a large ventricular septal defect?
Olprinone demonstrates positive inotropic and selective vasodilator effects in patients with large VSDs, suggesting potential therapeutic benefit.
Answers are grounded in this paper and cite their sources.
Olprinone was associated with favorable hemodynamics in large VSD; leaves open its therapeutic role pending controlled trials.
The hemodynamic effects of olprinone, a newly synthesized phosphodiesterase (PDE) III inhibitor, were assessed in patients with a large cardiac left-to-right shunt. Ten patients with a large ventricular septal defect (VSD) were evaluated during cardiac catheterization. Olprinone was administered as a bolus, 20 microg/kg body weight, and hemodynamic data were obtained before and after the administration. Heart rate and systemic flow increased significantly after administration. On the other hand, olprinone significantly reduced left and right atrial pressure, the systolic pulmonary/arterial pressure ratio, and systemic vascular resistance. However, pulmonary flow and pulmonary vascular resistance were not changed. These results suggested that olprinone had a positive inotropic effect and selective vasodilator effect on patients with a large ventricular left-to-right shunt. Thus, PDE inhibitors may be beneficial for the treatment of patients with a large VSD.
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Momoi et al. (2000) studied Large ventricular septal defect (VSD) (n=10). Olprinone vs. Baseline (before administration) was evaluated on Hemodynamic parameters (heart rate, systemic flow, atrial pressure, systemic vascular resistance). Olprinone significantly increased heart rate and systemic flow, and reduced atrial pressure and systemic vascular resistance in patients with a large ventricular septal defect.
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