Why the study?
Does the concomitant use of PDE inhibitors (milrinone or olprinone) and low-dose catecholamines improve hemodynamics in patients undergoing elective CABG?
Does the concomitant use of PDE inhibitors (milrinone or olprinone) and low-dose catecholamines improve hemodynamics in patients undergoing elective CABG?
Concomitant use of PDE inhibitors and low-dose catecholamines facilitates weaning from cardiopulmonary bypass and maintains excellent hemodynamics after CABG without causing significant hypotension.
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May support olprinone for greater preload reduction post-CABG; extends observational data but leaves open need for randomized weaning trials.
Orime et al. (1999) studied this question.
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