Why the study?
Does milrinone administered before aortic cross-clamping preserve intramyocardial cAMP concentration during cardiopulmonary bypass in adult patients undergoing CABG?
Population
20 adult patients undergoing coronary artery bypass grafting with cardiopulmonary bypass (CPB)
Comparison
Milrinone administered through the bypass pump… vs Placebo administered through the bypass pump 10…
Design
RCT, randomized
Follow-up
until end of cardiopulmonary bypass
Authors
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Single pre-clamp milrinone preserves myocardial cAMP in CABG; confirms biochemical efficacy during CPB in this RCT.
Does milrinone administered before aortic cross-clamping preserve intramyocardial cAMP concentration during cardiopulmonary bypass in adult patients undergoing CABG?
Administration of a single dose of milrinone before aortic cross-clamping significantly preserves intramyocardial cAMP concentration during cardiopulmonary bypass.
Janelle et al. (2001) studied this question.
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