Why the study?
Does preemptive milrinone or amrinone therapy improve postoperative hemodynamics and reduce dopamine requirements in patients undergoing coronary artery bypass grafting?
Population
45 patients undergoing coronary artery bypass grafting
Comparison
Milrinone or amrinone administered at release of… vs Placebo administered at release of aortic…
Design
RCT, randomly administered
Follow-up
10 hours postoperative
Authors
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Supports preemptive PDE-III inhibition to optimize post-CABG hemodynamics; extends RCT evidence for inotropic prophylaxis.
Does preemptive milrinone or amrinone therapy improve postoperative hemodynamics and reduce dopamine requirements in patients undergoing coronary artery bypass grafting?
Preemptive administration of milrinone or amrinone during CABG improves postoperative cardiac function and oxygen transport while reducing dopamine requirements and markers of cellular injury.
Kikura et al. (2002) studied this question.
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