Key result
A low-dose aspirin regimen (0.42 mg/kg/day for 7 days) caused greater than 90% inhibition of TxB2 formation and substantially reduced alpha-granule release and thrombin generation.
Why the study?
Does low-dose aspirin reduce platelet activation and thrombin generation at the site of plug formation in healthy volunteers?
Population
7 healthy volunteers
Design
Other
Follow-up
7 days
Authors
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Early local activation in healthy volunteers merits study in disease states; leaves open clinical relevance for bleeding or thrombosis.
Does low-dose aspirin reduce platelet activation and thrombin generation at the site of plug formation in healthy volunteers?
Effect estimate: >90% inhibition
Low-dose aspirin substantially inhibits thromboxane B2 formation, alpha-granule release, and thrombin generation during early hemostasis in vivo, demonstrating that thrombin generation is promoted by platelet activation.
Kyrle et al. (1987) studied Healthy (n=7). Low-dose aspirin was evaluated on TxB2 formation, alpha-granule release, and thrombin generation (>90% inhibition). A low-dose aspirin regimen (0.42 mg/kg/day for 7 days) caused greater than 90% inhibition of TxB2 formation and substantially reduced alpha-granule release and thrombin generation.
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