Key result
A 7-day administration of low-dose aspirin (75 mg/d) significantly reduced the maximum rates of prothrombin removal by 29% (P=0.008) and alpha-thrombin B-chain generation by 27.2% (P=0.022).
Why the study?
Does aspirin 75 mg/d reduce thrombin generation and coagulation reactions at the site of microvascular injury in healthy subjects?
Population
12 healthy subjects
Comparison
Aspirin 75 mg/d for 7 days vs Baseline (before aspirin ingestion)
Design
Cohort
Follow-up
7 days
Authors
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Provides foundational in vivo coagulation kinetics data; leaves open validation in patients and aspirin effects on bleeding.
Does aspirin 75 mg/d reduce thrombin generation and coagulation reactions at the site of microvascular injury in healthy subjects?
Effect estimate: 29% reduction
p-value: p=0.008
Low-dose aspirin significantly impairs thrombin generation and related coagulation reactions at the site of microvascular injury.
Undas et al. (2001) studied Healthy (n=12). Aspirin vs. Baseline (before aspirin ingestion) was evaluated on Maximum rate of prothrombin removal (29% reduction, p=0.008). A 7-day administration of low-dose aspirin (75 mg/d) significantly reduced the maximum rates of prothrombin removal by 29% (P=0.008) and alpha-thrombin B-chain generation by 27.2% (P=0.022).
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