Key result
An HPLC-UV method was developed and validated for the simultaneous determination of Pioglitazone and Clopidogrel, demonstrating linearity over 20-120 ppm with correlation coefficients >0.999.
A validated HPLC method was successfully developed for the simultaneous determination of clopidogrel and pioglitazone in bulk and dosage forms.
Facilitates simultaneous drug quantification in labs; leaves open clinical adoption and therapeutic monitoring utility.
A high performance liquid chromatographic method with UV detection was developed and validated for simultaneous determination of Pioglitazone and Clopidogrel. Separation was performed on a C18 column by isocratic elution with a mobile phase of Methanol: Acetonitrile: Water (80:10:10) at pH 4.6. The UV detection was set at 230 nm. The method proved to be specific, accurate, precise and linear over the concentration ranges of 20-120ppm for both Pioglitazone and Clopidogrel with correlation coefficients always >0.999 for both drugs. The intra-day and inter-day precision and accuracy were less than 2 for both analytes. DOI: http://dx.doi.org/10.3329/ijpls.v2i1.14580 International Journal of Pharmaceutical and Life Sciences Vol.2(1) 2013: 1-9
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Kumar et al. (2013) studied this question. HPLC-UV method was evaluated on Method validation (linearity, precision, accuracy, LOD, LOQ). An HPLC-UV method was developed and validated for the simultaneous determination of Pioglitazone and Clopidogrel, demonstrating linearity over 20-120 ppm with correlation coefficients >0.999.
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