Key result
High-frequency oscillations (80-800 Hz) are complex neuronal events sensitive to recording conditions, requiring basic standards to facilitate data sharing and interpretation in epilepsy research.
Adopting basic standards for recording and analyzing high-frequency oscillations will facilitate data sharing and aid in understanding their role as biomarkers of epileptogenic tissue.
May improve HFO data comparability; leaves open validation as epilepsy biomarkers.
Pathological high-frequency oscillations (HFOs) (80-800 Hz) are considered biomarkers of epileptogenic tissue, but the underlying complex neuronal events are not well understood. Here, we identify and discuss several outstanding issues or conundrums in regards to the recording, analysis, and interpretation of HFOs in the epileptic brain to critically highlight what is known and what is not about these enigmatic events. High-frequency oscillations reflect a range of neuronal processes contributing to overlapping frequencies from the lower 80 Hz to the very fast spectral frequency bands. Given their complex neuronal nature, HFOs are extremely sensitive to recording conditions and analytical approaches. We provide a list of recommendations that could help to obtain comparable HFO signals in clinical and basic epilepsy research. Adopting basic standards will facilitate data sharing and interpretation that collectively will aid in understanding the role of HFOs in health and disease for translational purpose.
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Prida et al. (2015) conducted a review in Epilepsy. High-frequency oscillations (HFOs) recording and analysis was evaluated. High-frequency oscillations (80-800 Hz) are complex neuronal events sensitive to recording conditions, requiring basic standards to facilitate data sharing and interpretation in epilepsy research.
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