Key result
Late exercise preconditioning significantly elevated BNP and NPR-A levels and decreased NPR-C protein levels in rats subjected to high-intensity exercise.
Why the study?
Late exercise preconditioning confers cardioprotection against high-intensity exercise-induced injury, but changes in BNP, NPR-A, and NPR-C expression during this process required investigation.
Does late exercise preconditioning alter the expression of BNP, NPR-A, and NPR-C to provide cardioprotection against high-intensity exercise-induced myocardial injury in rats?
RCT (n=100)
randomly divided
Does late exercise preconditioning alter the expression of BNP, NPR-A, and NPR-C to provide cardioprotection against high-intensity exercise-induced myocardial injury in rats?
Late exercise preconditioning may protect against high-intensity exercise-induced myocardial injury by increasing BNP synthesis and up-regulating NPR-A while down-regulating NPR-C.
Answers are grounded in this paper and cite their sources.
LEP-associated BNP/NPR-A/C shifts in rats may clarify preconditioning mechanisms; leaves open human relevance pending clinical data.
Late exercise preconditioning (LEP) is known to have a cardioprotection against myocardial injury induced by high-intensity exercise (HE). B-type natriuretic peptide (BNP) carries out the majority of its effects through interaction with natriuretic peptide receptor A (NPR-A) and natriuretic peptide receptor C (NPR-C) to protect heart health. This study aims to investigate the changes in the expression of BNP, NPR-A and NPR-C, during LEP-induced cardioprotection. Male Sprague–Dawley rats (n = 100) were randomly divided into 4 experimental groups (25/group). Rats of LEP model were subjected to an intermittent exercise consisting of 4 periods, each period including 10 min of running at 30 m/min (approximately 75% VO2max) followed by 10 min of intermittent rest. A model of HE-induced myocardial injury was developed by subjecting rats to one bout of high-intensity treadmill exercise at 35 m/min (approximately 80% VO2max) and 0% grade. Following LEP, the levels of BNP and NPR-A were significantly increased, whereas the protein levels of NPR-C were tended to be lower. A group of rats were subjected to LEP followed by HE, and the levels of BNP and NPR-A were significantly elevated in this group, whereas there was a significant decrease in the protein levels of NPR-C. LEP may increase the synthesis and secretion of BNP to assist the cardioprotection via up-regulating of NPR-A and down-regulating of NPR-C.
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Wan et al. (2021) conducted an RCT in myocardial injury induced by high-intensity exercise (n=100). Late exercise preconditioning (LEP) vs. High-intensity exercise without LEP was evaluated on Changes in the expression of BNP, NPR-A and NPR-C. Late exercise preconditioning significantly elevated BNP and NPR-A levels and decreased NPR-C protein levels in rats subjected to high-intensity exercise.
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