Key result
Young hypertensive patients with normal two-dimensional left atrial size had significantly reduced left atrial ejection fraction (50.44% vs. 57.85%) and impaired strain parameters compared to healthy controls.
Why the study?
The study aimed to detect early left atrial function abnormalities using four-dimensional auto left atrial quantification in young hypertensive patients with normal two-dimensional left atrial volume index and analyse correlations with clinical metabolic indicators.
Does 4D Auto LAQ detect early left atrial dysfunction in young hypertensive patients with normal 2D-LAVI compared to healthy controls?
Observational (n=111)
No
Does 4D Auto LAQ detect early left atrial dysfunction in young hypertensive patients with normal 2D-LAVI compared to healthy controls?
4D Auto LAQ echocardiography can detect early subclinical left atrial dysfunction in young hypertensive patients before left atrial enlargement occurs.
May signal subclinical LA impairment in young hypertensives; hypothesis-generating and requires prospective validation before clinical adoption.
BACKGROUND: This study aimed to detect early left atrial (LA) function abnormalities in young hypertensive patients with a normal two-dimensional LA volume index (2D-LAVI) using four-dimensional auto LA quantification technology (4D Auto LAQ) and to analyse correlations between LA strain parameters and clinical metabolic indicators. METHODS: This study enrolled 70 young patients who underwent standard hypertension treatment or diagnosis at the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, from October 2023 to July 2024 and 41 control volunteers enrolled during the same period. LA volume and strain parameters were evaluated with a 4D Auto LAQ. A correlation analysis was conducted between the clinical and strain parameters. RESULTS: Compared with the control group, young hypertensive patients presented significantly greater LA minimum volume (LAVmin), LA minimum volume index (LAVImin) and LA pre-atrial volume (LAVpreA) values (all p < 0.001). The LA ejection fraction (LAEF) was reduced in young hypertensive patients (57.85%±4.47% vs. 50.44%±5.96%, p < 0.001), along with LA reservoir longitudinal strain (25.00% [20.50-29.50%] vs. 20.00% [16.00-24.25%], p < 0.001), LA conduit longitudinal strain (-16.32%±4.19% vs. -11.37%±4.65%, p < 0.001), LA contraction longitudinal strain (-12.27%±2.85% vs. -9.60 ± 4.12, p < 0.001), LA reservoir circumferential strain (34.32%±6.90% vs. 28.41%±6.95%, p < 0.001), LA conduit circumferential strain (-17.90%±4.84% vs. -11.46%±4.96%, p < 0.001), and LA contraction circumferential strain (-18.54%±4.85% vs. -16.23%±6.11%, p < 0.05). Multivariate linear regression analysis revealed that body mass index (BMI), triglyceride (TG), and uric acid (UA) were negatively and independently correlated with LA longitudinal strain. CONCLUSIONS: In young hypertensive patients with normal 2D-LAVI, while LAVmin, LAVImin and LAVpreA are elevated, the LAEF and LA reservoir, conduit, and contraction strain are notably reduced. The application of 4D Auto LAQ technology may highlight altered values in young hypertensive patients with normal 2D-LAVI. 4D Auto LAQ may serve as a valuable tool for clinicians in the early detection and assessment of LA dysfunction in young hypertensive patients.
No takes yet. Share an insight, caveat, or question.
Ping et al. (2025) conducted an observational in Hypertension with normal left atrial size (n=111). Hypertension vs. Healthy controls was evaluated on Left atrial ejection fraction (LAEF) (Cohen's d 1.357, 95% CI 0.929-1.78, p=<0.001). Young hypertensive patients with normal two-dimensional left atrial size had significantly reduced left atrial ejection fraction (50.44% vs. 57.85%) and impaired strain parameters compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: