Key result
Physical exercise modifies the release of circulating microparticles that affect angiogenesis, playing a role in both physiological adaptations and pathological states.
Why the study?
Does physical exercise affect the release of circulating microparticles with angiogenic potential?
Does physical exercise affect the release of circulating microparticles with angiogenic potential?
This review highlights that physical exercise modulates the release of circulating microparticles, which may play a key role in exercise-induced angiogenesis and vascular adaptation.
MP concentration shifts in CVD may signal inter-organ crosstalk; review leaves open biomarker or therapeutic roles pending targeted trials.
Cellular communication has a fundamental role in both human physiological and pathological states and various mechanisms are involved in the crosstalk between organs. Among these, microparticles (MPs) have an important involvement. MPs are a subtype of extracellular vesicles produced by a variety of cells following activation or apoptosis. They are normally present in physiological conditions, but their concentration varies in pathological states such as cardiovascular disease, diabetes mellitus, or cancer. Acute and chronic physical exercise are able to modify MPs amounts as well. Among various actions, exercise-responsive MPs affect angiogenesis, the process through which new blood vessels grow from pre-existing vessels. Usually, the neo vascular growth has functional role; but an aberrant neovascularization accompanies several oncogenic, ischemic, or inflammatory diseases. In addition, angiogenesis is one of the key adaptations to physical exercise and training. In the present review, we report evidence regarding the effect of various typologies of exercise on circulating MPs that are able to affect angiogenesis.
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Credico et al. (2020) reported a review. Physical exercise was evaluated on Release of circulating microparticles with angiogenic potential. Physical exercise modifies the release of circulating microparticles that affect angiogenesis, playing a role in both physiological adaptations and pathological states.
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