Key result
Pharmacological strategies targeting reperfusion injury have largely failed to translate to clinical practice due to a lack of testable drugs, despite promising experimental results.
Design
Review
Authors
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Reperfusion protocols should remain unchanged; leaves open development of testable agents targeting mPTP and calcium handling.
Highlights the need to develop clinically testable drugs targeting known mechanisms of lethal reperfusion injury, such as mPTP opening and calcium handling alterations.
INSERTE et al. (2009) conducted a review in Reperfusion injury. Pharmacological targets for reperfusion injury was evaluated. Pharmacological strategies targeting reperfusion injury have largely failed to translate to clinical practice due to a lack of testable drugs, despite promising experimental results.
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