Key result
Elevated fibrinolytic factors, particularly tPA/PAI-1 complex, predict increased risk of myocardial infarction in established CAD.
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An impaired fibrinolytic function, as evidenced by increased plasma concentrations of PAI-1, tPA antigen and tPA/PAI-1 complex, or a decreased capacity to release active tPA on exercise, is more common in individuals suffering from myocardial infarction. These factors, especially the tPA/PA-1 complex, also predict myocardial infarction in patients with manifest coronary heart disease, such as angina pectoris or a previous myocardial infarction. There is a highly statistically significant correlation between tPA/PAI-1 complex and both PAI-1 and tPA antigen. It is important to test these factors in prospective studies on healthy individuals.
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Björn Wiman (1999) conducted a review in Coronary heart disease. Fibrinolytic factors (PAI-1, tPA antigen, tPA/PAI-1 complex) was evaluated on Myocardial infarction. Increased plasma concentrations of fibrinolytic factors, especially the tPA/PAI-1 complex, predict myocardial infarction in patients with manifest coronary heart disease.
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