Key result
HnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability during haematopoietic cell differentiation via their KH-domains.
HnRNP K and hnRNP E1/E2 play a key role in post-transcriptional gene regulation, specifically mRNA translation and stability, during haematopoietic cell differentiation.
May inform models of hematopoietic differentiation disorders; leaves open clinical translation of KH-domain targeting.
Studies on the post-transcriptional regulation of gene expression in haematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. HnRNP K and hnRNP E1/E2 share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KH-domains are components of a modular system, which enables these proteins to engage in both, protein/nucleic acid and protein/protein interactions, the latter generating connectivity to cell signalling events. As components of different mRNA-protein complexes, hnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability in haematopoietic cell differentiation.
No takes yet. Share an insight, caveat, or question.
Ostareck‐Lederer et al. (2004) conducted a review in Haematopoietic cell differentiation. hnRNP K and hnRNP E1/E2 was evaluated. HnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability during haematopoietic cell differentiation via their KH-domains.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: