Key result
Depression is associated with increased cardiovascular mortality, but evidence that treating it with SSRI antidepressants reduces cardiovascular morbidity and mortality remains uncertain.
Why the study?
Does treating depression with SSRI antidepressants reduce cardiovascular morbidity and mortality in patients with cardiovascular disease?
Population
Patients with cardiovascular disease, particularly post-myocardial infarction (MI) depression
Design
Review
Authors
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Warrants depression screening in cardiac patients; leaves open whether SSRI treatment reduces cardiovascular events.
Does treating depression with SSRI antidepressants reduce cardiovascular morbidity and mortality in patients with cardiovascular disease?
While depression is firmly established as a predictor of cardiovascular mortality, evidence that treating it with SSRIs reduces medical adverse events remains suggestive rather than definitive.
Alexander H. Glassman (2008) conducted a review in Depression and Cardiovascular Disease. Depression was evaluated. Depression is associated with increased cardiovascular mortality, but evidence that treating it with SSRI antidepressants reduces cardiovascular morbidity and mortality remains uncertain.
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