Key result
Sustained stretch via mechanosensitive channels increased postshock VF complexity, while stretch-induced deformation decreased vulnerability to electric shocks in a 2D electro-mechanical model.
Why the study?
Does sustained stretch affect vulnerability to electric shocks and postshock VF patterns in a 2D electro-mechanical model of cardiac tissue?
Does sustained stretch affect vulnerability to electric shocks and postshock VF patterns in a 2D electro-mechanical model of cardiac tissue?
In a computational model, stretch-induced deformation decreases vulnerability to electric shocks, while mechanosensitive channel recruitment increases the complexity of postshock ventricular fibrillation patterns.
Model suggests stretch elevates DFT via postshock changes; leaves open in vivo confirmation before guiding defibrillation.
Ventricular dilatation increases the defibrillation threshold (DFT). In order to elucidate the mechanisms responsible for this increase, the present article investigates changes in the postshock behavior of the myocardium upon stretch. A two-dimensional electro-mechanical model of cardiac tissue incorporating heterogeneous fiber orientation was used to explore the effect of sustained stretch on postshock behavior via (a) recruitment of mechanosensitive channels (MSC) and (b) tissue deformation and concomitant changes in tissue conductivities. Recruitment of MSC had no influence on vulnerability to electric shocks as compared to control, but increased the complexity of postshock VF patterns. Stretch-induced deformation and changes in tissue conductivities resulted in a decrease in vulnerability to electric shocks.
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Gurev et al. (2006) studied Ventricular dilatation and postshock arrhythmogenesis. Sustained stretch vs. Control was evaluated on Vulnerability to electric shocks and complexity of postshock VF patterns. Sustained stretch via mechanosensitive channels increased postshock VF complexity, while stretch-induced deformation decreased vulnerability to electric shocks in a 2D electro-mechanical model.
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