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Paget's disease of bone is a localized, monostotic or polyostotic disease characterized by increased bone remodeling, bone hypertrophy, and abnormal bone structure that leads in symptomatic patients to pain and bone deformity. Complications involve the bones (fractures and neoplastic degeneration), joints (osteoarthritis), and nervous system. The short-term objective of treatment is to alleviate bone pain, and the long-term objective is to minimize or prevent the progression of the disease.Pathology, Epidemiology, and EtiologyPagetic bone is characterized by major disorganization in both the architecture and the lamellar texture of bone. These abnormalities are the results of major disturbances in bone . . .
Delmas et al. (Thu,) studied this question.