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Recently, a study published in the Immunity has elucidated the mechanism by which amyloid-β (Aβ) induces lipid droplet accumulation in microglia in Alzheimer's disease[1]. The study identified diacylglycerol O-acyltransferase 2 (DGAT2) as a key enzyme playing a critical role in this process.
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Chen et al. (2026) studied this question.
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