Key result
High visit-to-visit blood pressure variability was significantly associated with worse cardiac diastolic function (E/e' mean difference 1.82) and greater carotid atherosclerosis compared to low variability.
Why the study?
Does high visit-to-visit blood pressure variability associate with worse cardiac diastolic function and carotid atherosclerosis in older adults?
Cross-Sectional (n=144)
No
Does high visit-to-visit blood pressure variability associate with worse cardiac diastolic function and carotid atherosclerosis in older adults?
High visit-to-visit blood pressure variability is associated with worse diastolic function and increased carotid atherosclerosis, suggesting it may be a risk factor for these conditions.
High visit-to-visit BP variability was associated with worse diastolic function and carotid atherosclerosis; leaves open whether it predicts outcomes or warrants intervention.
BACKGROUND: The associations between visit-to-visit blood pressure (BP) variability and cardiac function and carotid atherosclerosis is not clear. METHODS: Study subjects were 144 subjects (80 were female, aged 73 ± 9 years) who underwent echocardiography and cervical ultrasonography. The ratio of early ventricular filling velocity to early diastolic mitral annular velocity (E/e'), ejection fraction, left ventricular mass index (LVMI), and maximum intima-media thickness (max-IMT) of the carotid artery were compared between the highest (high variability) and lowest (low variability) tertiles of the standard deviation of systolic BP (9.9 ± 3.5 mmHg). RESULTS: E/e' and max-IMT were significantly greater in the high variability group than in the low variability group after adjusting for age, sex, baseline systolic BP, and other covariates (high variability vs. low variability; E/e': 13.03 ± 5.33 vs. 10.66 ± 3.30, multivariate-adjusted difference (β) = 1.82, 95% confidence interval 0.06-3.58; max-IMT: 1.65 ± 0.43 mm vs. 1.42 ± 0.46 mm, β = 0.20 mm, 95% confidence interval 0.03-0.36 mm). There were no significant differences in LVMI or ejection fraction. CONCLUSION: These results indicate that high visit-to-visit BP variability is associated with diastolic function and carotid atherosclerosis, and is a possible risk factor for diastolic dysfunction and atherosclerosis.
No takes yet. Share an insight, caveat, or question.
Okada et al. (2014) conducted a cross-sectional in Subjects undergoing echocardiography and cervical ultrasonography (n=144). High visit-to-visit blood pressure variability vs. Low visit-to-visit blood pressure variability was evaluated on Ratio of early ventricular filling velocity to early diastolic mitral annular velocity (E/e') (MD 1.82, 95% CI 0.06-3.58, p=<0.05). High visit-to-visit blood pressure variability was significantly associated with worse cardiac diastolic function (E/e' mean difference 1.82) and greater carotid atherosclerosis compared to low variability.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: