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September 6, 2016American Journal of HypertensionOpen Access

Visit-to-visit DBP variability was associated with higher all-cause (HR 1.18 per 1 SD, 95% CI 1.01-1.37) and CV mortality (HR 1.35, 95% CI 1.05-1.73).

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Why the study?

Does visit-to-visit blood pressure variability increase the risk of mortality and cardiovascular outcomes in well-functioning older adults?

Population

1,877 well-functioning elders in the Health, Aging, and Body Composition Study

Design

Cohort

Follow-up

average 8.5 years

Authors

CWChenkai WuMSMichael G. ShlipakRSRobert S. Stawski

Discussion

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Overview

DBP variability may flag higher mortality risk in older adults; leaves open whether targeting it improves outcomes.

Structured PICO

Does visit-to-visit blood pressure variability increase the risk of mortality and cardiovascular outcomes in well-functioning older adults?

P
Population
1,877 well-functioning elders in the Health, Aging, and Body Composition Study
I
Intervention
Visit-to-visit blood pressure (SBP and DBP) variability
O
Outcome
Mortality (all-cause and cardiovascular), incident myocardial infarction (MI), and incident strokehard clinical

Visit-to-visit diastolic blood pressure variability and considerable changes in blood pressure are independent risk factors for all-cause and cardiovascular mortality in older adults.

Cite This Study

Wu et al. (2016) studied this question.

synapsesocial.com/papers/6a7faf22812a481b9a5f26e7https://doi.org/10.1093/ajh/hpw106
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