What question did this study set out to answer?

The aim is to assess how resins and activated charcoal affect the absorption of digoxin, carbamazepine, and frusemide.

February 1, 1988British Journal of Clinical PharmacologyOpen Access

Effects of resins and activated charcoal on the absorption of digoxin, carbamazepine and frusemide.

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Authors

PNPertti J. NeuvonenGeneral / Preventive / Lipids KKKari T. KivistöTampere University EHE. L. HirvisaloUniversity of Helsinki

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Implication

Randomized trial investigates resins and activated charcoal affecting absorption of drugs in healthy volunteers, suggesting significant implications for drug efficacy.

Key Points

The aim is to assess how resins and activated charcoal affect the absorption of digoxin, carbamazepine, and frusemide.
Cross-over study involving six healthy volunteers
Single doses of colestipol, cholestyramine, activated charcoal, or water administered with test drugs
Plasma, urine concentrations and urine volumes measured for up to 72 hours
Absorption of digoxin reduced by cholestyramine (30-40%, P<0.05) and greatly by charcoal (96%)
Carbamazepine absorption reduced by charcoal (90%) and slightly by colestipol (10%)
Frusemide absorption diminished significantly by all agents, with bioavailability reduced by colestipol (80%), cholestyramine (95%), and charcoal (99.5%)

Cite This Study

Neuvonen et al. (1988) studied this question.

synapsesocial.com/papers/6a63a1489a2e487662c2126e https://doi.org/10.1111/j.1365-2125.1988.tb03295.x

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Implication

Randomized trial investigates resins and activated charcoal affecting absorption of drugs in healthy volunteers, suggesting significant implications for drug efficacy.

Effects of resins and activated charcoal on the absorption of digoxin, carbamazepine and frusemide.

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of resins and activated charcoal on the absorption of digoxin, carbamazepine and frusemide.

Discussion

Member takes

Implication

Key Points

Cite This Study

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