Key result
Gene therapy and RNA interference represent potential future therapeutic interventions for stimulating angiogenesis, protecting against reperfusion injury, and treating ischemic heart disease.
This review highlights the potential of molecular biologic techniques, including gene therapy and RNA interference, in understanding and treating ischemic heart disease.
Should not change ischemic heart disease management; leaves open gene therapy potential pending randomized trials.
Molecular biologic techniques have a variety of applications in the study of ischemic heart disease, including roles in elucidating cardiac genetic changes resulting from ischemia as well as in developing therapeutic interventions to treat ischemic heart disease. This review describes recent studies documenting genetic changes associated with myocardial ischemia and infarction as well as those investigating the safety and effectiveness of gene therapy for stimulating angiogenesis, protecting the heart against reperfusion injury, and treating heart failure. Also discussed are future research directions, including the potential use of RNA interference and combined stem cell therapy and gene therapy for the treatment of cardiovascular disease.
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Nordlie et al. (2006) conducted a review in Ischemic heart disease. Gene and RNA interference therapy was evaluated. Gene therapy and RNA interference represent potential future therapeutic interventions for stimulating angiogenesis, protecting against reperfusion injury, and treating ischemic heart disease.
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