Key result
Cardiac-specific overexpression of triadin 1 in mice altered SR Ca2+ handling, leading to depressed basal contractility and a blunted response to beta-adrenergic agonists.
Population
Transgenic (TG) mice and wild-type (WT) mice
Comparison
Cardiac-specific overexpression of triadin 1 vs Wild-type (WT) mice
Design
Preclinical
Authors
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Triadin 1 overexpression effects in mice warrant no clinical action; hypothesis-generating for SR Ca2+ roles in human cardiomyopathy.
Cardiac-specific overexpression of triadin 1 in mice alters SR Ca2+ handling, leading to depressed basal contractility and a blunted response to beta-adrenergic agonists.
Uwe Kirchhefer (2004) studied this question. Cardiac-specific overexpression of triadin 1 vs. Wild-type (WT) mice was evaluated on SR Ca2+ handling and contractility. Cardiac-specific overexpression of triadin 1 in mice altered SR Ca2+ handling, leading to depressed basal contractility and a blunted response to beta-adrenergic agonists.
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