Key result
This review examines current knowledge on mechanisms of adiponectin-associated perivascular function and how they become disordered in obesity, highlighting potential new therapeutic approaches.
This review highlights the role of perivascular fat and adiponectin in vascular function, suggesting potential therapeutic targets for obesity and type II diabetes.
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May identify adiponectin targets in perivascular fat for obesity-related vascular disease; leaves open need for trials before clinical consideration.
The concept that fat cells could influence the circulation and indeed cardiac function has been in existence for ≥20 years and has gained a wide interest and no less excitement as evidence has accrued to suggest that such effects may be profound enough to explain disease states, such as hypertension and metabolic changes associated with obesity and type II diabetes mellitus. This ATVB in Focus intends to examine our current knowledge in this field, and suggests mechanisms that may be responsible for normal perivascular function and how they become disordered in obesity. There is the tantalizing prospect of developing new therapeutic approaches to keep obese individuals healthy and redesignating type II diabetes mellitus as a vascular disease.
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Withers et al. (2014) conducted a review in Vascular disease, obesity, and type II diabetes mellitus. This review examines current knowledge on mechanisms of adiponectin-associated perivascular function and how they become disordered in obesity, highlighting potential new therapeutic approaches.
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