Key result
In apoE(-/-) and apoE*3-Leiden mice, atherogenesis is associated with compensatory enlargement, medial thinning, and elastolysis, with progressive lumen diameter decrease and >70% stenosis occurring only in carotid arteries.
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Compensatory remodeling may preserve lumen despite plaques in mice; leaves open translation to human lesion progression and clinical events.
Lutgens et al. (2001) studied Atherosclerosis. apoE(-/-) and apoE*3-Leiden mouse models vs. nondiseased arterial wall was evaluated on Vascular remodeling parameters (plaque thickness, compensatory enlargement, lumen diameter, stenosis, media thickness). In apoE(-/-) and apoE*3-Leiden mice, atherogenesis is associated with compensatory enlargement, medial thinning, and elastolysis, with progressive lumen diameter decrease and >70% stenosis occurring only in carotid arteries.
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