Why the study?
Does AT1 or AT2 receptor antagonism prevent Angiotensin II-induced neointimal thickening in balloon-injured rat carotid arteries?
Population
Male Wistar rats with balloon injury of the left common carotid artery
Comparison
Subcutaneous infusion for 2 weeks with… vs Control groups receiving Angiotensin II alone…
Design
Preclinical
Follow-up
2 weeks
Authors
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AT1 but not AT2 antagonism may limit Ang II-driven neointimal hyperplasia after injury; leaves open translation to human restenosis prevention.
Does AT1 or AT2 receptor antagonism prevent Angiotensin II-induced neointimal thickening in balloon-injured rat carotid arteries?
AT1, but not AT2, receptors mediate the progression of neointimal thickening induced by delayed application of Angiotensin II in the injured rat carotid artery.
Kleef et al. (1996) studied this question.
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