Facile visible-light promoted copper-catalyzed aerobic oxidative C-N coupling between 2-aminopyridine and terminal alkynes at room temperature via C[triple bond, length as m-dash]C triple bond cleavage is described. This reaction allows direct synthesis of biologically important pyridyl amides by utilization of commercially available starting materials without the need for bases/external oxidants.
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Ragupathi et al. (2016) studied this question.
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