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The Greek word “nanos,” which means “very small,” is the origin of the word “nano,” which refers to the nanoscale, which is often defined as 1–100 nm 1 , 2 . It has made it possible to develop cutting-edge colloidal formulations that alter the pharmacological properties of drugs 3 . Investigators in the domains of pharmaceutical technology, medicine, and biomedical engineering have all shown a keen interest in nanotechnology in recent decades. Nanomaterials (NMs) are structures that have at Least one dimension smaller than 100 nm and are distinctive in their physical, chemical, and/or biological characteristics due to their nanostructure 4 . One area of nanotechnology is called “nanomedicine” focuses on using nanoformulation to treat and prevent disease 5 . Creating a good pharmaceutical formulation, or a high-quality, safe, and effective medication formulation while increasing the bioavailability of the active pharmaceutical ingredients (APIs), is one of the main objectives of nanotechnology and nanomedicine. Among the several NMs, dendrimers have been emphasized recently as promising nanostructures, and because of their unique physicochemical and structural characteristics, their potential as pharmacological excipients have been investigated 6 . Highly branched polymers with readily mutable surfaces are called dendrimers. These polymers might be thought of in pharmaceutical science as excipients in the creation of various medicinal formulations. Dendrimers are ideal for the safe and efficient transportation of medications because of their precise molecular weight, availability of internal cavities, high degree of branching, biocompatibility, and nanoscale size 7 . Dendrimers are very sensitive to the type of functional group present on their terminals when it comes to their water solubility. Dendrimers with hydrophilic terminals like amines, hydroxyls, or polyethylene glycol (PEG) chains are very soluble in water, whereas dendrimers with neutral or hydrophobic groups at the end-caps like acetyl groups are rather insoluble in water 8 . Because of their special qualities that set them apart from other NMs, dendrimers are highly useful in biomedical engineering and diagnostics, particularly in medication and gene delivery systems. Drug safety has been shown to be enhanced and drug-related toxicity has been decreased by the use of dendrimers for drug targeting and delivery 9 . A charged functional group is affixed to the surface of the molecule in dendrimers that are charged. These charged groups might be negatively charged (anionic) or positively charged (cationic). In various fields such as gene delivery, targeted medication delivery, cancer therapy, protein transport, biological interfaces, colloidal stability, and tissue engineering, charged dendrimers are significant and have numerous uses. Because charged dendrimers may interact with biological systems and modify their behavior, they have a broad range of applications in biology, medicine, and materials research 10 . An extensive summary of the synthesis, characterisation, and medicinal uses of charged dendrimers is given in this paper.
Karati et al. (Tue,) studied this question.