Key result
COVID-19 infection can present with neurally mediated/reflex syncope as a chief complaint, with no recurrence reported during follow-up in two observed cases.
Why the study?
COVID-19 infection can present with atypical symptoms such as syncope.
Case Report (n=2)
COVID-19 infection can present atypically with neurally mediated/reflex syncope, even in the absence of other initial symptoms.
May prompt COVID-19 testing for unexplained syncope; hypothesis-generating for reflex mechanisms, needing prospective confirmation.
COVID-19 infection can present with atypical symptoms such as syncope. We reported 2 patients who presented to our emergency department with syncope as a chief complaint. One patient did not have any other symptoms while the other patient developed severe pneumonia later during hospitalization. The cardiac workup including electrocardiogram, cardiac monitoring, and echocardiogram were unremarkable. Both patients were diagnosed with neurally mediated/reflex syncope secondary to COVID-19. No recurrence was reported during follow-up. We then performed a literature review and described previous cases focusing on clinical presentation and the likely mechanism of syncope.
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Alranini et al. (2022) conducted a case report in COVID-19 and syncope (n=2). COVID-19 infection was evaluated on Syncope recurrence. COVID-19 infection can present with neurally mediated/reflex syncope as a chief complaint, with no recurrence reported during follow-up in two observed cases.
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