Key result
Direct delivery of hydrogen persulfide using novel esterase- and phosphatase-sensitive prodrugs reaffirmed that S-persulfidation decreases glyceraldehyde 3-phosphate dehydrogenase activity.
This study provides a novel prodrug approach for directly delivering hydrogen persulfide, expanding the available tools to study sulfur signaling mechanisms.
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New H2S2 prodrugs enable mechanistic persulfidation studies; leaves open clinical translation.
A general strategy of delivering hydrogen persulfide (H 2 S 2 ) is described herein. Esterase- and phosphatase-sensitive H 2 S 2 prodrugs with tunable release rates have been synthesized. Their utility is validated in examining protein S-persulfidation. With this unique approach of directly delivering H 2 S 2, our findings reaffirmed that S-persulfidation leads to decreased activity of glyceraldehyde 3-phosphate dehydrogenase. This new approach complements available prodrugs/donors that directly deliver a single species, including hydrogen sulfide, perthiol, and COS, and will be very useful as part of the toolbox for delineating the mechanisms of sulfur signaling.
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Yu et al. (2017) studied this question. Hydrogen persulfide (H2S2) prodrugs was evaluated on Protein S-persulfidation and glyceraldehyde 3-phosphate dehydrogenase activity. Direct delivery of hydrogen persulfide using novel esterase- and phosphatase-sensitive prodrugs reaffirmed that S-persulfidation decreases glyceraldehyde 3-phosphate dehydrogenase activity.
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