Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis

Baomei Wang; Jong‐Hyung Lim; Tetsuhiro Kajikawa; Xiaofei Li; Bruce A. Vallance; Niki M. Moutsopoulos; Triantafyllos Chavakis; George Hajishengallis

doi:10.1016/j.celrep.2019.01.054

February 1, 2019Cell ReportsOpen Access

Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis

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Key Points

This research explores how macrophage β2-integrins affect IL-22 production in the context of colitis.
Utilized mouse models of lethal colitis to study the role of β2-integrins.
Analyzed the mechanistic relationship involving Rac1, ROS, and noncanonical NLRP3 inflammasome.
Evaluated the induction of IL-1β and its effect on ILC3-derived IL-22.
Confirm that β2-integrin expression on macrophages is crucial for IL-1β-dependent IL-22 responses in colitis.
Demonstrated the Rac1/ROS pathway as a significant mediator in promoting IL-22 production during colitis.
Findings suggest a potential link between human LAD1 and increased colitis susceptibility.

Implication

Investigates how macrophage β2-integrins influence IL-22 production in colitis, suggesting a protective role.

Abstract

mice from lethal colitis. β2-integrin expression on macrophages is mechanistically linked to Rac1/ROS-mediated induction of noncanonical-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome-dependent IL-1β production, which promotes ILC3-derived IL-22. Therefore, β2-integrins are required for protective IL-1β-dependent IL-22 responses in colitis, and the identified mechanism may underlie the association of human LAD1 with colitis.

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Cite This Study

Wang et al. (2019) studied this question.

synapsesocial.com/papers/6a63b0c34c0a08ff99b6e2b1 https://doi.org/10.1016/j.celrep.2019.01.054

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Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis

Key Points

Implication

Abstract

Discussion

Cite This Study

Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis

Key Points

Implication

Abstract

Discussion

Cite This Study

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