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May 27, 2021Science

CRISPR diagnostics

Omar O. Abudayyeh Jonathan S. Gootenberg

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Abstract

New CRISPR enzyme activities add to the nucleic acid detection arsenal

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Abudayyeh et al. (2021) studied this question.

synapsesocial.com/papers/6a63ba46809dd4a9e2c1f9ef https://doi.org/10.1126/science.abi9335

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Noncanonical crRNAs derived from host transcripts enable multiplexable RNA detection by Cas9Original Research · 2021 · 152 citations
2C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effectorOriginal Research · 2016 · 2,353 citations
3CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activityOriginal Research · 2018 · 4,473 citations
4Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6Diagnostic Study · 2018 · 2,634 citations
5Nucleic acid detection with CRISPR-Cas13a/C2c2Original Research · 2017 · 3,857 citations

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