What question did this study set out to answer?

This research aims to investigate the antitumor activity of IL-12/15/18-preactivated NK cells and their sustained effector function against established tumors.

December 3, 2012The Journal of Experimental MedicineOpen Access

Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors

View Full Paper

Ask AI

Bookmark

This research aims to investigate the antitumor activity of IL-12/15/18-preactivated NK cells and their sustained effector function against established tumors.
Single injection of IL-12/15/18-preactivated NK cells was administered with irradiation to mouse models.
Comparison made with naive and IL-15- or IL-2-pretreated NK cells.
Assessment of tumor growth after NK cell transfer and radiation therapy.
IL-12/15/18-preactivated NK cells significantly reduced tumor growth compared to naive and other treatment groups (exact metrics not provided).
Increased IL-2Rα (CD25) expression was observed in preactivated NK cells, suggesting a relationship with CD4+ T cell activity.
Human IL-12/15/18-preactivated NK cells demonstrated sustained effector function in vitro.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Randomized trial shows improved antitumor activity in mice through IL-12/15/18-preactivated NK cells and radiation therapy, suggesting adaptive and innate immune linkages.

Cite This Study

Ni et al. (2012) studied this question.

synapsesocial.com/papers/6a63bc753eb69703d1b73aa3 https://doi.org/10.1084/jem.20120944

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial shows improved antitumor activity in mice through IL-12/15/18-preactivated NK cells and radiation therapy, suggesting adaptive and innate immune linkages.

Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors

Key Points

Discussion

Implication

Cite This Study

Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider