Key result
Supplemental antioxidants prevented hyperglycemia-induced elevation of oxidative stress and PKC activity, and inhibited decreases in myocardial (Na,K)-ATPase and calcium ATPases in rats.
Why the study?
Do supplemental antioxidants prevent metabolic abnormalities in the myocardium of rats with diabetes or experimental galactosemia?
Population
Rats with diabetes or experimental galactosemia of 2 months duration
Design
Preclinical
Follow-up
2 months
Authors
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Antioxidant effects on hyperglycemia-induced myocardial stress merit human trials; leaves open any clinical translation from rodent data.
Do supplemental antioxidants prevent metabolic abnormalities in the myocardium of rats with diabetes or experimental galactosemia?
Antioxidant therapy prevents hyperglycemia-induced metabolic abnormalities in the rat myocardium, suggesting a potential mechanism to mitigate diabetic heart disease.
Kowluru et al. (2000) studied Hyperglycemia (diabetes and experimental galactosemia). Supplemental antioxidants vs. No supplemental antioxidants was evaluated on Oxidative stress (TBARS, lipid fluorescent products), PKC activity, and (Na,K)-ATPase and calcium ATPases activities. Supplemental antioxidants prevented hyperglycemia-induced elevation of oxidative stress and PKC activity, and inhibited decreases in myocardial (Na,K)-ATPase and calcium ATPases in rats.
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