Key result
The binding of Ca2+ to the regulatory site of cardiac troponin C is length dependent, which is driven by a dependence on the number of attached cross bridges.
The length dependence of Ca2+ sensitivity in cardiac muscle is mechanistically driven by the number of attached cross bridges rather than sarcomere length per se.
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No immediate clinical implications for contractility modulation; leaves open cross-bridge mechanisms as therapeutic targets in human myocardium.
Hofmann et al. (1987) studied this question. Sarcomere length extension and cross-bridge attachment was evaluated on Ca2+ binding to cardiac troponin C. The binding of Ca2+ to the regulatory site of cardiac troponin C is length dependent, which is driven by a dependence on the number of attached cross bridges.
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