Key result
Deletion of the PAC1 receptor in excitatory neurons resulted in spatial memory deficits, locomotor impairments, diminished dendritic spine density, and decreased mitochondrial content.
Population
Tamoxifen-inducible conditional knockout mouse model with PAC1 receptor gene deletion in Camk2a-expressing excitatory neurons
Comparison
PAC1 receptor gene deletion vs control
Design
Preclinical animal model study
Authors
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Neuronal PAC1 deletion impairs structural plasticity; leaves open its role in human cognitive or motor disorders.
PAC1 is a key modulator of synaptic integrity, neuronal plasticity, and energy homeostasis in excitatory neurons, highlighting its potential as a therapeutic target in neurological disorders.
Jansen et al. (2025) studied this question. PAC1 receptor gene (Adcyap1r1) deletion was evaluated on Spatial memory, locomotor function, and neuronal structure. Deletion of the PAC1 receptor in excitatory neurons resulted in spatial memory deficits, locomotor impairments, diminished dendritic spine density, and decreased mitochondrial content.
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