Effects of exercise training and sex on dynamic responses of O₂ uptake in type 2 diabetes

Effects of training and sex on oxygen uptake dynamics during exercise in type 2 diabetes mellitus (T2DM) are not well established. We tested the hypotheses that exercise training improves the time constant of the primary phase of oxygen uptake (τ p oxygen uptake) and with greater effect in males than females. Forty-one subjects with T2DM were assigned to 2 training groups (T male , T female ) and 2 control groups (C male , C female ), and were assessed before and after a 12-week intervention period. Twelve weeks of aerobic/resistance training was performed 3 times per week, 60–90 min per session. Assessments included ventilatory threshold (VT), peak oxygen uptake, τ p oxygen uptake (80%VT), and dynamic responses of cardiac output, mean arterial pressure and systemic vascular conductance (80%VT). Training significantly decreased τ p oxygen uptake in males by a mean of 20% (T male = 42.7 ± 6.2 to 34.3 ± 7.2 s) and females by a mean of 16% (T female = 42.2 ± 9.3 to 35.4 ± 8.6 s); whereas τ p oxygen uptake was not affected in controls (C male = 41.6 ± 9.8 to 42.9 ± 7.6 s; C female = 40.4 ± 12.2 to 40.6 ± 13.4 s). Training increased peak oxygen uptake in both sexes (12%–13%) but did not alter systemic cardiovascular dynamics in either sex. Training improved oxygen uptake dynamics to a similar extent in males and females in the absence of changes in systemic cardiovascular dynamics. Novelty Similar training improvements in oxygen uptake dynamics were observed in males and females with T2DM. In both sexes these improvements occurred without changes in systemic cardiovascular dynamics.