Effects Of Endurance Training On Muscular V’O2 Kinetics In Type 2 Diabetes Patients

PURPOSE: Maximal V’O2 is known to increase with endurance exercise interventions. Recently, a method has been developed to assess muscular V’O2 (V’O2musc) kinetics from heart rate (HR) and pulmonary V’O2 responses to work rate changes, which allows a better differentiation between cardiovascular system and muscular metabolism. Cardiorespiratory kinetics were analyzed in type 2 diabeties subjects before and after an endurance exercise intervention. METHODS: 9 male subjects (61 ± 9 years, 33 ± 5 kg·m−2) were tested for peak V’O2 (V’O2peak), glycemic parameters and cardiorespiratory kinetics using pseudo randomized binary work rate changes (30/80 W). To estimate V’O2musc and cardiorespiratory kinetics, the method of Hoffmann et al. (2013) was applied. Kinetics were summarized by maximum of cross correlation functions (CCFmax) and equivalents of time constants. Two pre-tests (Pre I, Pre II) within a 4 week period and a post-test after 12 weeks of endurance training were performed. Differences between the tests were analyzed via a two factorial ANOVA. P<= 0.05 was considered significant. RESULTS: Table 1 shows the results of Pre I, Pre II and Post tests (mean +− SD, * significantly different from Post). CONCLUSION: Endurance training improves both, V’O2musc and heart rate kinetics in type 2 diabetes patients. This was in accordance with the increase in V’O2peak. In contrast, no changes in glycemic parameters could be observed. V’O2musc kinetics, assessed via moderate WR changes and independent of motivation, can be seen as an indicator for cardiorespiratory fitness and might be useful to measure increases in cardiorespiratory regulation.Table: No title available.Reference: Hoffmann et al. (2013); EJAP, 113:1745-1754.