Key result
Type 2 diabetes mellitus was associated with lower peak oxygen uptake and lower muscle oxygenation during rest, warm-up, and recovery phases compared with healthy controls (P<0.05).
Why the study?
The role of impaired oxygen extraction on peak oxygen uptake has been extensively studied using noninvasive and indirect methods in diabetic patients and healthy participants.
Are muscle microcirculatory responses to incremental exercise correlated with peak oxygen uptake in individuals with and without type 2 diabetes mellitus?
Observational (n=44)
Are muscle microcirculatory responses to incremental exercise correlated with peak oxygen uptake in individuals with and without type 2 diabetes mellitus?
p-value: p=<0.05
Direct measurement of muscle oxygenation using NIRS during incremental exercise correlates with peak oxygen uptake, demonstrating impaired microcirculatory responses in patients with type 2 diabetes.
Impaired muscle oxygenation may limit fitness in type 2 diabetes; hypothesis-generating and requires prospective trials before clinical adoption.
Background: The role of impaired oxygen extraction on peak oxygen uptake (O2peak) has been extensively studied using noninvasive and indirect methods in both diabetic patients and healthy participants. Methods: A total of 22 participants with type 2 diabetes mellitus [T2DM; median (range) age: 60 (47–70) years] and 22 controls [58 (52–69) years] with no history of diabetes were recruited (reference no. 201812135RINB). Subjects performed an exhaustive incremental exercise and were evaluated using a gas analyzer and near-infrared spectroscopy (NIRS) to determine O2peak and changes in muscle oxygenation (SmO2) in the vastus lateralis, respectively. Measurements were taken at rest, warm-up, a period during exercise when SmO2 reached a minimum saturation plateau, and recovery. The microcirculatory responses of the vastus lateralis muscle during incremental exercise in patients with T2DM were compared with those in control individuals, and the correlation between changes in SmO2 and O2peak was estimated. Results: The diabetic group demonstrated lower O2peak, peak workload, peak heart rate, peak minute ventilation (all P < 0.05), and lower SmO2 during the rest, warm-up, and recovery phases (all P < 0.05) compared with the control group. A correlation was observed between the change in SmO2 between the warm-up and plateau value and the O2peak (r = 0.608, P = 0.006). Conclusions: The results obtained in this study using NIRS support the feasibility of directly measuring changes in muscle SmO2 magnitudes to estimate the contributions of peripheral active muscle to systemic O2 uptake (O2) during incremental exercise.
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Lu et al. (2022) conducted an observational in Type 2 diabetes mellitus (n=44). Type 2 diabetes mellitus vs. Controls with no history of diabetes was evaluated on Peak oxygen uptake (O2peak) and muscle oxygenation (SmO2) (p=<0.05). Type 2 diabetes mellitus was associated with lower peak oxygen uptake and lower muscle oxygenation during rest, warm-up, and recovery phases compared with healthy controls (P<0.05).
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