Key result
Plasma lipoproteins, including VLDL, LDL, Lp[a], and HDL, appear to function as components of the innate immune system by preventing infections and detoxifying bacterial products.
This review highlights the concept that plasma lipoproteins play an important role in the host immune response and innate immunity against infections.
Hypothesis-generating for lipoproteins in innate immunity; leaves open any role in infection risk or lipid therapy.
Plasma lipoproteins (VLDL, LDL, Lp[a] and HDL) function primarily in lipid transport among tissues and organs. However, cumulative evidence suggests that lipoproteins may also prevent bacterial, viral and parasitic infections and are therefore a component of innate immunity. Lipoproteins can also detoxify lipopolysaccharide and lipoteichoic acid. Infections can induce oxidation of LDL, and oxLDL in turn plays important anti-infective roles and protects against endotoxin-induced tissue damage. There is also evidence that apo(a) is protective against pathogens. Taken together, the evidence suggests that it might be valuable to introduce the concept that plasma lipoproteins belong in the realm of host immune response.
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Runlin Han (2010) reported a review. Plasma lipoproteins was evaluated. Plasma lipoproteins, including VLDL, LDL, Lp[a], and HDL, appear to function as components of the innate immune system by preventing infections and detoxifying bacterial products.
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