Key result
Apolipoprotein A-I and other lipoproteins play a key role in host defense by binding and neutralizing endotoxins such as lipopolysaccharide.
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Highlights the role of HDL and apolipoprotein A-I in innate immunity and endotoxin neutralization.
In addition to the well-recognized transport function of lipoproteins, a large body of evidence has demonstrated that lipoproteins also play an important role in host defense as part of the innate immune system (for review, see Ref. 1). One of the key defensive functions is the ability of HDL and other lipoproteins to bind endotoxin (lipopolysaccharide, LPS) and other bacterial products and neutralize their toxic effects. In this issue of the Journal of Lipid Research, Wang et al. (2) provide insights into the structural requirements for LPS neutralization by apolipoprotein A-I.
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Grünfeld et al. (2008) conducted an editorial in Innate immunity and lipoprotein function. Apolipoprotein A-I was evaluated. Apolipoprotein A-I and other lipoproteins play a key role in host defense by binding and neutralizing endotoxins such as lipopolysaccharide.
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