Key result
Apolipoprotein A-1 generally acts as an anti-inflammatory molecule, but specific post-translational modifications during systemic inflammation can transform it into a proinflammatory molecule.
Design
Review
Authors
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apoA-1 anti-inflammatory effects may support atheroprotection; leaves open therapeutic translation pending higher-level evidence.
Understanding the mechanisms driving apoA-1 and HDL towards pro- or anti-inflammatory states is clinically important, especially given the failure of CETP inhibitors to prevent cardiovascular disease.
Vuilleumier et al. (2013) conducted a review in Cardiovascular disease and inflammation. Apolipoprotein A-1 (apoA-1) was evaluated. Apolipoprotein A-1 generally acts as an anti-inflammatory molecule, but specific post-translational modifications during systemic inflammation can transform it into a proinflammatory molecule.
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