What question did this study set out to answer?

To review recent advances regarding how HDL-associated proteins mediate protective vascular and anti-inflammatory functions beyond reverse cholesterol transport.

August 14, 2026Current Opinion in Lipidology

HDL-associated proteins affecting CVD and systemic inflammation

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Authors

SDSamuel DelkUniversity of California, Los Angeles SRSrinivasa T. ReddyUniversity of California, Los Angeles

Discussion

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Implication

Review uncovers that HDL-associated proteins mitigate systemic inflammation and cardiovascular disease independently of cholesterol transport, highlighting functional protein targets for therapy.

Key Points

To review recent advances regarding how HDL-associated proteins mediate protective vascular and anti-inflammatory functions beyond reverse cholesterol transport.
Reviewed recent preclinical and clinical investigations assessing the biological mechanisms of HDL-associated proteins in cardiovascular disease, chronic kidney disease, and sepsis models.
Synthesized molecular evidence on cellular pathways including mitochondrial maintenance, autophagy, arterial LDL transcytosis, and endosomal-lysosomal endotoxin clearance.
ApoM levels exhibit an inverse relationship with adverse outcomes in chronic kidney disease and related cardiovascular complications by regulating mitochondrial function and autophagy.
ApoA-I, serum amyloid A, and SR-B1 suppress atherogenesis by inhibiting endothelial LDL transcytosis and arterial proteoglycan entrapment.
HDL-bound endotoxin undergoes SR-B1-dependent degradation via endosome-lysosome pathways to attenuate IL-1β activation, while CETP inhibition increases HDL and lowers sepsis mortality in mice.

Cite This Study

Delk et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec6eab70b84ec8b912f01 https://doi.org/10.1097/mol.0000000000001052

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Implication

Review uncovers that HDL-associated proteins mitigate systemic inflammation and cardiovascular disease independently of cholesterol transport, highlighting functional protein targets for therapy.

HDL-associated proteins affecting CVD and systemic inflammation

Discussion

Member takes

Implication

Key Points

Cite This Study

HDL-associated proteins affecting CVD and systemic inflammation

Discussion

Member takes

Implication

Key Points

Cite This Study

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