What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Type 2 diabetes mellitus with or without cardiac autonomic neuropathy (n=17). Intervention: Cardiac autonomic neuropathy vs. Diabetic patients without cardiac autonomic neuropathy. Primary outcome: Sample entropy (SampEn) of heart rate variability (m=2, r=0.3*SD) (p=0.04).

January 1, 2009BioMedical Engineering OnLineOpen Access

Identifying diabetic patients with cardiac autonomic neuropathy by heart rate complexity analysis

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Key result

Diabetic patients with cardiac autonomic neuropathy had significantly lower sample entropy of heart rate variability compared to those without the condition (1.09 vs 1.48, p=0.04).

Why the study?

Does heart rate complexity analysis using Sample Entropy identify asymptomatic cardiac autonomic neuropathy in patients with Type 2 diabetes?

Population

17 patients with Type 2 diabetes mellitus. Exclusions: history of cardiac pathology, hypertension, or…

Comparison

Heart rate variability complexity analysis using… vs Comparison between diabetic patients with CAN…

Design

Cross-sectional

Authors

AKAhsan H. KhandokerElectrophysiology HJHerbert F. JelinekKhalifa University of Science and Technology MPMarimuthu PalaniswamiAustralian National University

Discussion

Member takes

Implication

May aid early CAN detection in diabetes; leaves open prospective validation before clinical adoption.

Study Design

Type

Cross-Sectional (n=17)

Multicenter

Structured PICO

Does heart rate complexity analysis using Sample Entropy identify asymptomatic cardiac autonomic neuropathy in patients with Type 2 diabetes?

Population

17 patients with Type 2 diabetes mellitus (9 with and 8 without cardiac autonomic neuropathy) underwent 20-minute ECG recordings to assess heart rate variability and complexity.

Exposure

Heart rate variability (HRV) complexity analysis using Sample Entropy (SampEn) and Poincaré plot indexes from 20-minute supine ECG recordings.

Comparator

Comparison between diabetic patients with CAN (CAN+) and without CAN (CAN-).

Outcome

Prediction of CAN+ using a classification tree based on SampEn and Poincaré plot indexes (sensitivity and specificity).surrogate

Main Result

Absolute Event Rate: 1.09% vs 1.48%

p-value: p=0.04

Sample entropy of heart rate variability from short-term ECG recordings can accurately identify asymptomatic cardiac autonomic neuropathy in patients with Type 2 diabetes.

Limitations

Small sample size (17 patients)
Use of only one test (lying to standing HRV) to classify CAN+ and CAN-
Lack of non-diabetic control subjects to evaluate the baseline effect of diabetes on heart rate complexity
Small sample size

Cite This Study

Khandoker et al. (2009) conducted a cross-sectional in Type 2 diabetes mellitus with or without cardiac autonomic neuropathy (n=17). Cardiac autonomic neuropathy vs. Diabetic patients without cardiac autonomic neuropathy was evaluated on Sample entropy (SampEn) of heart rate variability (m=2, r=0.3*SD) (p=0.04). Diabetic patients with cardiac autonomic neuropathy had significantly lower sample entropy of heart rate variability compared to those without the condition (1.09 vs 1.48, p=0.04).

synapsesocial.com/papers/6a63d515b28cf853587a7329 https://doi.org/10.1186/1475-925x-8-3

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Identifying diabetic patients with cardiac autonomic neuropathy by heart rate complexity analysis

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Identifying diabetic patients with cardiac autonomic neuropathy by heart rate complexity analysis

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider