Key result
Stem cell tissue engineering shows myocardial regenerative potential, limited by poor retention and massive cell death.
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Advances in cardiac tissue engineering have recently focused on utilizing stem cells to regenerate infarcted and scarred myocardium. Due to their proliferative nature and tremendous potential for differentiation, stem cells are presently being investigated for clinical applications. Unfortunately, limiting factors such as massive cell death and poor retention have hampered clinical outcomes. Consequently, the development of an efficient delivery system for stem cells to the target site is essential. The use of innovative tissue engineering techniques has opened up new horizons within the field of cellular cardiomyoplasty. This paper will present a comprehensive overview of the recent advancements in stem cell technology destined for myocardial tissue repair. In addition, the multidisciplinary approach to tissue engineering presented here will provide the reader with insight into the clinical realization of cellular cardiomyoplasty.
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Huu et al. (2013) conducted a review in infarcted and scarred myocardium. Stem cell-based cardiac therapies and tissue engineering was evaluated. Stem cell-based tissue engineering shows potential for cellular cardiomyoplasty to regenerate infarcted myocardium, though clinical outcomes are hampered by massive cell death and poor retention.
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